Reagents for DPP IV Research
Dipeptidyl peptidase IV (DPP IV), a widely distributed, multifunctional transmembrane serine protease, has attracted considerable interest in recent times. It modulates the activity of several peptide hormones by cleaving Xaa-Pro or Xaa-Ala from their NH2-terminal. DPP IV functions as a dimer and each monomeric subunit has an α/β hydrolase domain and an eight-bladed β-propeller domain. Both these domains participate in inhibitor binding at the active site. Of considerable interest is the cleavage of glucagon-like peptide-1 (GLP-1) by DPP IV.
GLP-1 is shown to be important in maintaining glucose homeostasis. It blocks glucagon secretion, delays gastric emptying, and stimulates insulin biosynthesis. GLP-1 has been under consideration as an alternate treatment for type II diabetes. However, its short half-life (<1 min) severely limits its use as a treatment option. To overcome this difficulty, inhibition DPP IV has been proposed as a viable option and DPP IV inhibitors are shown to improve glucose tolerance in animal models of type II diabetes.
Assay Kits
| Ürün | Kat. No. |
|---|---|
| InnoZyme™ DPP IV Activity Assay Kit | CBA097 |
| InnoZyme™ DPP IV Immunocapture Activity Assay | CBA085 |
Antibody
Enzymes
| Ürün | Kat. No. |
|---|---|
| Dipeptidyl Peptidase IV (CD26), Porcine Kidney | 317640 |
| Dipeptidylpeptidase IV, His•Tag®, Human, Recombinant, S. frugiperda | 317639 |
| Dipeptidylpeptidase IV, Human Placenta | 317630 |
Substrate
| Ürün | Kat. No. |
|---|---|
| Dipeptidylpeptidase IV Substrate I, Fluorogenic | 125510 |
Inhibitor
| Ürün | Kat. No. |
|---|---|
| Dipeptidylpeptidase IV Inhibitor I | 416200 |
